发生教学法在行列式概念教学中的运用

发生教学法是基于数学史的一种教学方式,以行列式概念为例,分析发生教学法在大学数学教学中的应用.首先阐述发生教学法的缘起,生物发生律类推到数学教育催生发生教学法;其次介绍发生教学法的策略,发生教学法借鉴历史引入主题,重现知识再发现过程;最后用发生教学法设计行列式概念教学,展示详细教学流程,并说明设计理由,促进在大学数学教学中推广发生教学法.     

双向认知网络物理层安全策略建模及仿真研究

为提高移动通信系统的性能,构建了一个存在主网络干扰和窃听者的双向认知中继网络的物理层安全传输模型,设计了一种中继选择和功率分配的联合优化策略,用于对抗窃听者,保护收发节点的信息传输。通过仿真分析得出,此非凸优化问题限制条件较多,难以保证粒子群优化算法随机生成的初始解的可行性,从而造成求解困难。提出了一种基于可变网格优化和粒子群优化算法的混合优化算法。仿真结果表明此算法提高了次级网络的保密速率,提升了次级网络的安全性能。     

Uncoupled PID Control of Coupled Multi-Agent Nonlinear Uncertain systems

In this paper, PID (proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

基于深度学习的建筑物识别

针对随着城市化的快速发展,城市与城市间的辨识度越来越弱,城市地标的概念越来越热门这一现象,提出了一种基于深度学习的建筑物识别方法;使用改进的Faster R-CNN算法作为训练模型,首先,将需要识别的图片输入深度神经网络,提取出特征框图;然后,模型通过区域建议网络预测目标建筑物所在位置的区域建议,并将这些区域建议映射到特征框图上,RoI Pooling层将这些区域建议转换成固定大小的特征框图;最后使用非极大值抑制从预测边界框中移除相似的结果,得到预测边界框以及边框中目标建筑物的类别和概率;实验结果表明:在训练数据集充足的条件下,使用此方法对地标建筑物的识别率能达到90. 8%,通过与其他模型比较分析,该模型具有较好的识别效果。     

三角代数上Lie积为平方零元的非线性Jordan高阶可导映射

设U是一个 2-无挠的三角代数,D ={d_n}_n∈N是U上一个Lie积为平方零元的非线性Jordan高阶可导映射。证明了三角代数U上的每一个Lie积为平方零元的非线性Jordan高阶可导映射都是高阶导子。作为结论的应用,得到套代数或 2-无挠的上三角分块矩阵代数上的每一个Lie积为平方零元的非线性Jordan高阶可导映射都是高阶导子。     

2018年天文学热点回眸

 天文学是一门以观测为基础的学科，其发展主要依靠观测和数据的支持。基于SAO/NASA Astrophysics Data System天文物理学数据系统中高被引文章并结合热点新闻报道，回顾了2018年天文学热点的进展和发现，以观测和基础研究、仪器研制及工具开发两大方面论述了2018年天文学研究热点。     

桉树生态营林的理论探索与实践

桉树生态环境问题是世界性难题,迫切需要开展生态营林理论的探索与实践。本文通过系统地研究营林措施与人工林生态服务功能关系的变化规律,分析不同营林措施对桉树人工林生态服务功能的作用机制,并通过桉树生态营林实践,建立起现代桉树生态营林理论体系。文中提出生态营林的定义、生态营林原则和生态营林的理论体系。6年的生态营林实践表明,采取"低干扰、低投入、低污染"的生态营林方式,获得"高产量、高价值、高效率"的营林效果,实现长短结合、一般用材与珍贵用材结合、木材生产与生态服务协同提升的生态营林目标。该理论是解决当今桉树人工林木材生产和生态服务失衡以及生物安全、土壤安全、生态安全问题,实现高质量发展的重要理论基础,对推动我国现代林业高质量发展具有重要的指导作用。     

一维离散平均曲率方程Neumann问题解的存在性

用紧向量场方程的解集连通理论给出一维离散平均曲率方程Neumann问题的上下解方法, 并给出其解的存在性结果.